流感病毒包膜与宿主细胞内体融合
中文名称
通路描述
病毒结合靶细胞表面并被内吞后，内体中的低pH导致病毒HA（血凝素）发生结构变化，释放其HA2亚基的融合肽，使其与内体膜相互作用。HA2（插入至病毒膜）的跨膜域和融合肽（插入至内体膜）在酸性pH结构下呈邻近状态。随后，多个血凝素分子的协同结构变化打开一个孔，使病毒RNA复合体（RNP）能够进入宿主细胞胞质。
英文描述
Fusion of the Influenza Virion to the Host Cell Endosome After the virus binds to the target cell surface and is endocytosed, the low pH of the endosome causes the viral HA (hemagglutinin) to undergo a structural change which frees the fusion peptide of its HA2 subunit allowing it to interact with the endosome membrane. The transmembrane domain of the HA2 (inserted into the viral membrane) and the fusion peptide (inserted into the endosomal membrane) are in juxtaposition in the acidic pH structure of HA. The concerted structural change of several hemagglutinin molecules then opens a pore through which the viral RNP will be able to pass into the host cell cytosol.
所含基因
9 个基因