出芽
中文名称
通路描述
流感病毒颗粒从感染细胞出芽的过程尚不完全清楚。M1在内质网膜上积累被认为是启动出芽形成的触发因素。出芽形成持续进行，直到病毒内核心完全被包被。出芽过程的完成需要出芽底部的膜融合。虽然M1被认为是出芽形成的驱动力，但其他病毒和细胞蛋白已被证明影响病毒颗粒的大小和形状。通常，流感病毒颗粒呈球形或丝状，这种形态特征与M段（Bourmakina, 2003; Roberts, 1998）遗传相关。宿主因素如极化作用和肌动蛋白细胞骨架在决定丝状颗粒形状中起关键作用（Roberts, 1998; Simpson-Holley, 2002）。
英文描述
Budding The process by which influenza virus particles bud from an infected cell is not very well understood. Accumulation of M1 at the inner leaflet of the plasma membrane is thought to be the trigger for the initiation of bud formation. This bud formation continues until the inner core of the virus is completely enveloped. Completion of the budding process requires the membrane at the base of the bud to fuse. Although M1 is thought to be the driving force for bud formation, other viral and cellular proteins have been demonstrated to affect size and shape of the virus particle. Generally, influenza virus particles are either spherical or filamentous and this characteristic morphology is genetically linked to the M segment (Bourmakina, 2003; Roberts, 1998). Host factors such as polarization and the actin cytoskeleton play a critical role in determining the shape of filamentous particles (Roberts, 1998; Simpson-Holley, 2002).
所含基因
5 个基因