宿主细胞核内的病毒RNP复合物
中文名称
通路描述
病毒RNP复合物通过全长负链病毒RNA（vRNA）与病毒核衣壳（NP）和基质蛋白（M1）的相互作用在宿主细胞核内组装。体外纯化组分相互作用及表达各种组分组合的组织培养模型系统的研究已确立了NP和M1蛋白在组装具有病毒颗粒纯化vRNP的物理特性的复合物中的角色（参见Whittaker, 1996; Huang, 2001; Baudin, 2001）。病毒RNP复合物已在核质中以及核周区域发现，并与核基质或染色质结合，特别是对于vRNA结合复合物和M1蛋白（参见Elton, 2005; Garcia-Robles, 2005; Takizawa et al., 2006）。
英文描述
Viral RNP Complexes in the Host Cell Nucleus Viral RNP is assembled in the host cell nucleus through the interaction of full-length negative strand viral RNA (vRNA) and the viral nucleocapsid (NP) and matrix (M1) proteins. Studies of interactions of the purified components in vitro and of tissue culture model systems expressing various combinations of the components have established roles for both NP and M1 proteins in the assembly of a complex that has the physical properties of vRNP purified from virions and that can be exported from the host cell nucleus (Whittaker, 1996; Huang, 2001; Baudin, 2001). Viral RNP complexes have been found in the nucleoplasm, and also in the nuclear periphery, associated with the nuclear matrix or chromatin, particularly for vRNA-containing complexes and M1 protein (Elton, 2005; Garcia-Robles, 2005; Takizawa et al., 2006).
所含基因
6 个基因