NEP/NS2与细胞出口机器相互作用
中文名称
通路描述
病毒RNP复合物通过宿主细胞CRM1出口途径从核内导出（参见Fukuda, 1997; Neumann, 2000; 综述于Buolo, 2006）。vRNP复合物不直接与CRM1相互作用形成出口复合物。相反，一种额外的病毒蛋白核出口蛋白（NEP/NS2）作为适配体，结合病毒基质M1蛋白和CRM1，从而将病毒RNP与CRM1连接起来（参见Martin, 1991; O'Neill, 1998; Neumann, 2000; Akarsu, 2003）。CRM1/出口蛋白1复合物招募额外的宿主细胞蛋白，并穿越核孔进入细胞质。
英文描述
NEP/NS2 Interacts with the Cellular Export Machinery The viral RNP complex is exported from the nucleus via the host cell CRM1 export pathway (Fukuda, 1997; Neumann, 2000; reviewed in Buolo, 2006). The vRNP complex does not interact directly with CRM1 to form an export complex. Rather, an additional viral protein, nuclear export protein (NEP/NS2), acts as an adaptor, binding the viral matrix M1 protein and CRM1, thus linking the viral RNP with CRM1 (Martin, 1991; O'Neill, 1998; Neumann, 2000; Akarsu, 2003). The CRM1/exportin-1 complex recruits additional host cell proteins, and traverses the nuclear pore into the cytosol.
所含基因
34 个基因