端粒末端包装
中文名称
通路描述
处理和维护端粒涉及多个步骤，包括 C 链切除、由端粒酶介导的延伸以及 C 链合成。虽然该模块假设这些步骤呈线性进行，但在人类中，这些步骤如何协调以及可能涉及的其他事件尚不清楚。端粒 DNA 可以形成高阶结构。来自人类细胞的端粒 DNA 的电子显微镜证据表明，存在被称为端粒环（t-loops）的环状结构（Griffith 等人，1999）。t-loops 被认为是由 3' G 富集的单链悬突侵入双链端粒 TTAGGG 重复序列形成的。t-loop 的功能被认为是掩盖 3'端粒悬突。多种蛋白质因子可以结合端粒 DNA，并可能贡献于动态的高阶结构。
英文描述
Packaging Of Telomere Ends Multiple steps, including C-strand resection, telomerase-mediated elongation, and C-strand synthesis are involved in processing and maintaining the telomere. Though this module posits a linear transit for the steps, in humans it is not well understood how these steps are coordinated and what other events may be involved.
Telomeric DNA can form higher order structures. Electron microscopy of telomeric DNA isolated from human cells provided evidence for lariat-type structures termed telomeric loops, or t-loops (Griffith et al., 1999). t-loops are proposed to result from the invasion of the 3' G-rich single strand overhang into the double stranded telomeric TTAGGG repeat tract. The function of the t-loop is presumed to be the masking of the 3' telomeric overhang. Multiple protein factors can bind telomeric DNA and likely contribute to dynamic, higher order structures.
Telomeric DNA can form higher order structures. Electron microscopy of telomeric DNA isolated from human cells provided evidence for lariat-type structures termed telomeric loops, or t-loops (Griffith et al., 1999). t-loops are proposed to result from the invasion of the 3' G-rich single strand overhang into the double stranded telomeric TTAGGG repeat tract. The function of the t-loop is presumed to be the masking of the 3' telomeric overhang. Multiple protein factors can bind telomeric DNA and likely contribute to dynamic, higher order structures.
所含基因
32 个基因