SCF-beta-TrCP 介导的 Emi1 降解
中文名称
通路描述
Emi1 的早期有丝分裂降解需要 SCF beta-TrCP 泛素化酶复合物。beta-TrCP 与 Emi1 的结合发生在晚期的前期，并且需要 DSGxxS 共识基序的磷酸化以及 Cdk 介导的磷酸化。一种两步骤机制已被提出，即 Cdc2 对 Emi1 的磷酸化发生在 G2-M 转换之后，随后很快 beta-TrCP 结合到 DSGxxS 磷酸化位点。Emi1 然后被多泛素化并由 26S 蛋白酶体降解。
英文描述
SCF-beta-TrCP mediated degradation of Emi1 Emi1 destruction in early mitosis requires the SCF beta-TrCP ubiquitin ligase complex. Binding of beta-TrCP to Emi1 occurs in late prophase and requires phosphorylation at the DSGxxS consensus motif as well as Cdk mediated phosphorylation. A two-step mechanism has been proposed in which the phosphorylation of Emi1 by Cdc2 occurs after the G2-M transition followed soon after by binding of beta-TrCP to the DSGxxS phosphorylation sites. Emi1 is then poly-ubiquitinated and degraded by the 26S proteasome.
所含基因
42 个基因