APC/C:Cdc20 介导的 Securin 降解

中文名称

通路描述

有丝分裂后期姐妹染色单体的分离需要破坏有丝分裂抑制剂 Securin。Securin 与并抑制蛋白酶 separase。Separase 切割粘附蛋白亚基 Scc1，后者负责姐妹染色单体的粘附（综述在 Nasmyth et al., 2000）。Securin 的降解始于有丝分裂中期，在有丝分裂纺锤体检查点得到满足之后（Hagting et al., 2002）。

英文描述

APC/C:Cdc20 mediated degradation of Securin The separation of sister chromatids in anaphase requires the destruction of the anaphase inhibitor, securin. Securin associates with and inactivates the protease, separase. Separase cleaves the cohesin subunit, Scc1 that is responsible for the cohesion of sister chromatids (reviewed in Nasmyth et al., 2000). Securin destruction begins at metaphase after the mitotic spindle checkpoint has been satisfied (Hagting et al., 2002).

所含基因

55 个基因

ADRM1 ANAPC1 ANAPC10 ANAPC11 ANAPC15 ANAPC16 ANAPC2 ANAPC4 ANAPC5 ANAPC7 CDC16 CDC20 CDC23 CDC26 CDC27 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD6 PSMD7 PSMD8 PTTG1 RPS27A SEM1 UBA52 UBB UBC UBE2C UBE2D1 UBE2E1 UBE2S