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Cdc20:Phospho-APC/C mediated degradation of Cyclin A

Reactome ID: R-HSA-174184

中文名称

钙信号通路

通路描述

细胞外进入细胞的钙离子是信号钙离子的主要来源。钙离子的进入由跨质膜的较大电化学梯度驱动。细胞利用这一外部信号钙离子来源,通过激活具有不同特性的各种进入通道。电压门控通道(VOCs)存在于兴奋性细胞中,产生快速钙离子流,控制快速细胞过程。还有许多其他钙离子进入通道,例如受体操作通道(ROCs),例如谷氨酸受体(NMDARs)。此外还有第二信使操作通道(SMOCs)和储存操作通道(SOCs)。
英文描述
Cdc20:Phospho-APC/C mediated degradation of Cyclin A Cyclin A, functions in mitosis as well as DNA replication and is degraded in the interim by the APC/C to permit normal chromosome segregation, cell division, and the onset of S phase (see Lukas and Bartek, 2004). Cyclin A is initially degraded early in mitosis by APC/C:Cdc20 when the spindle checkpoint is still active and degradation of securin and cyclin B is inhibited.

所含基因

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