CLEC7A (Dectin-1) 诱导 NFAT 激活
中文名称
通路描述
CLEC7A (Dectin-1) 通过经典的钙调蛋白/NFAT 通路，经由 Syk 激活、磷脂酶 C-γ2 (PLCG2) 信号传导，增加可溶性 IP3（肌醇三磷酸）。IP3 能够结合内质网钙通道，导致细胞质内 Ca2+ influx。钙离子浓度的增加激活钙调蛋白，进而导致 NFAT 去磷酸化并转位至细胞核，触发基因转录和细胞外释放白细胞介素 -2（Plato et al. 2013, Goodridge et al. 2007, Mourao-Sa et al. 2011）。
英文描述
Transport and metabolism of PAPS PAPS (3'-phosphoadenosine-5'-phosphosulfate), which functions as a sulfate donor in the cell, is synthesized from sulfate and two molecules of ATP in a two-step process (Robbins & Lipmann 1958) catalyzed in vertebrates by the bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase (PAPSS; Venkatachalam et al. 1998). PAPS synthesis takes place in the cytosol, and it is either consumed there in the sulfonation of a variety of hormones and xenobiotics, or it is transported to the Golgi apparatus and consumed in the synthesis of proteoglycans like chondroitin sulfate. Two isoforms of the human PAPSS are known, mutations in one of which are associated with defects in proteoglycan biosynthesis (Girard et al. 1998, ul Haque et al. 1998).
所含基因
7 个基因