端粒 C 链（滞后链）合成
中文名称
通路描述
由于 DNA 的反平行性质，DNA 聚合化是单向的，一条链是不连续合成的。这条链称为滞后链。虽然滞后链上的聚合酶切换与领先链相似，但两条链的连续合成过程截然不同。短 DNA 片段，长约 100 个碱基，称为 Okazaki 片段，首先在 RNA-DNA 引物上合成。发生解链合成，即引物含 5'-末端的相邻 Okazaki 片段折叠成单链凸起结构。该凸起结构由内切酶切除，相邻 Okazaki 片段由 DNA 连接酶连接。
英文描述
Telomere C-strand (Lagging Strand) Synthesis Due to the antiparallel nature of DNA, DNA polymerization is unidirectional, and one strand is synthesized discontinuously. This strand is called the lagging strand. Although the polymerase switching on the lagging strand is very similar to that on the leading strand, the processive synthesis on the two strands proceeds quite differently. Short DNA fragments, about 100 bases long, called Okazaki fragments are synthesized on the RNA-DNA primers first. Strand-displacement synthesis occurs, whereby the primer-containing 5'-terminus of the adjacent Okazaki fragment is folded into a single-stranded flap structure. This flap structure is removed by endonucleases, and the adjacent Okazaki fragments are joined by DNA ligase.
所含基因
11 个基因