从 C 链移除中间体的 flap
中文名称
通路描述
两种内切酶，Dna2 和 flap 内切酶 1（FEN-1），负责解决新生 flap 结构（Tsurimoto 和 Stillman 1991）。酵母中的 Dna2 内切酶/解旋酶是约 172 kDa 的单亚基。人类 FEN-1 是约 42 kDa 的单链多肽。复制蛋白 A 调节内切酶在移除置换 flap 时的切换（Tsurimoto 等，1991）。
英文描述
Removal of the Flap Intermediate from the C-strand Two endonucleases, Dna2 and flap endonuclease 1 (FEN-1), are responsible for resolving the nascent flap structure (Tsurimoto and Stillman 1991). The Dna2 endonuclease/helicase in yeast is a monomer of approximately 172 kDa. Human FEN-1 is a single polypeptide of approximately 42 kDa. Replication Protein A regulates the switching of endonucleases during the removal of the displaced flap (Tsurimoto et al.1991).
所含基因
17 个基因