TNF 结合其生理受体
中文名称
通路描述
肿瘤坏死因子超家族（TNFSF）和肿瘤坏死因子受体超家族（TNFRSF）的成员在先天免疫和适应性免疫中起着至关重要的作用。这些成员涉及各种获得性或遗传性人类疾病，从脓毒症到自身免疫性疾病、同种异体排斥反应和癌症（So et al. 2006）。
英文描述
Activation of C3 and C5 The 3 pathways of complement activation converge on the cleavage of C3 by C3 convertases. C3 convertase cleaves C3 into C3a and C3b - a central step of complement activation. C3a remains in the fluid phase and acts as an anaphylatoxin, whereas C3b can form additional C3 convertases hastening the production of C3b. Besides, C3b binds to C3 convertases to form C5 convertase, which can act as an opsonin, or is degraded into fragments which cannot form an active convertase.
所含基因
5 个基因