晚期有丝分裂期 APC/C:Cdc20 向 APC/C:Cdh1 的转换
中文名称
通路描述
细胞周期中 APC/C 的活动必须适当调节，以确保其底物的及时降解。特别重要的是晚期有丝分裂期 APC/C:Cdc20 向 APC/C:Cdh1 的转换。APC/C 复合体和 Cdh1 的磷酸化均调节此转换。在有丝分裂期间，多个 APC/C 亚基被磷酸化，增加 APC/C:Cdc20 的活性。然而，有丝分裂 Cyclin:Cdk 复合物对 Cdh1 的磷酸化阻止其激活 APC/C。Cdc14a 在晚期有丝分裂期对 Cdh1 的去磷酸化导致 APC/C:Cdh1 激活（参见 Castro et al, 2005）。
英文描述
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase The activity of the APC/C must be appropriately regulated during the cell cycle to ensure the timely degradation of its substrates. Of particular importance is the conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase. Phosphorylation of both the APC/C complex and Cdh1 regulate this conversion. During mitosis, several APC/C subunits are phosphorylated increasing the activity of APC/C:Cdc20. However, phosphorylation of Cdh1 by mitotic Cyclin:Cdk complexes prevents it from activating the APC/C. Dephosphorylation of Cdh1 in late anaphase by Cdc14a results in the activation of APC/C:Cdh1 (reviewed in Castro et al, 2005).
所含基因
20 个基因