G1/S 期与早期有丝分裂期 APC/C 激活因子的调节
中文名称
通路描述
APC/C 由 Cdc20 或 Cdh1 激活。虽然两者都与 APC/C 结合，但它们结合细胞周期的不同阶段，其结合方式也不同（参见 Zachariae and Nasmyth, 1999）。Cdc20 的蛋白质水平随着细胞进入有丝分裂而增加，在有丝分裂退出时减少，仅在 M 期与 APC/C 结合。Cdh1 在 G1 期与 APC/C 结合。此相互作用在其他时期被 Cdk1 磷酸化抑制。
英文描述
Regulation of APC/C activators between G1/S and early anaphase The APC/C is activated by either Cdc20 or Cdh1. While both activators associate with the APC/C, they do so at different points in the cell cycle and their binding is regulated differently (see Zachariae and Nasmyth, 1999). Cdc20, whose protein levels increase as cells enter into mitosis and decrease upon mitotic exit, only associates with the APC/C during M phase. Cdh1 associates with the APC/C in G1. This interaction is inhibited at other times by Cdk1 phosphorylation.
所含基因
25 个基因