APC/C:Cdc20 介导的有丝分裂蛋白降解
中文名称
通路描述
有丝分裂激酶磷酸化 APC/C 核心亚基后，激活蛋白 Cdc20 被招募到 APC 上，促进多泛素化及随后降解有丝分裂 Cyclin（Cyclin A 和 Cyclin B）和蛋白 securin，后者在姐妹染色单体凝聚中起作用。这些蛋白的及时降解对于姐妹染色单体分离和有丝分裂退出时间的正确控制至关重要（参见 Zachariae and Nasmyth, 1999）。Cdc20 在晚期有丝分裂期被降解（参见 Owens and Hoyt, 2005）。
英文描述
APC/C:Cdc20 mediated degradation of mitotic proteins Following phosphorylation of the APC/C core subunits by mitotic kinases, the activating protein, Cdc20 is recruited to the APC and promotes the multiubiquitination and subsequent degradation of the mitotic cyclins (Cyclin A and Cyclin B) as well as the protein securin which functions in sister chromatid cohesion. Timely degradation of these proteins is essential for sister chromatid separation and the proper timing of exit from mitosis (See Zachariae and Nasmyth, 1999). Cdc20 is degraded late in mitosis (Reviewed in Owens and Hoyt, 2005)
所含基因
20 个基因