水杨酸与甘氨酸的共轭
中文名称
通路描述
在体内，阿司匹林（乙酰水杨酸）水解为水杨酸 (ST)。ST 可随后羟化为升麻酸，与葡萄糖醛酸共轭，或与甘氨酸共轭生成可经肾脏排泄的分子。此处注释了这三种共轭过程中的第三个。这是水杨酸代谢的主要途径，占其产物的 20-65%（Hutt et al, 1986）。共轭过程分两步进行。首先，ST 和 ATP 与辅酶 A 反应生成水杨酸-CoA (ST-CoA)、AMP 和焦磷酸，该反应由外源性/中链脂肪酸-CoA 连接酶 (Vessey et al. 2003) 催化。其次，ST-CoA 和甘氨酸反应生成升麻酸和辅酶 A (Mawal and Qureshi 1994)。
英文描述
Conjugation of salicylate with glycine In the body, aspirin (acetylsalicylic acid) is hydrolyzed to salicylate (ST). ST can then be hydroxylated to yield gentisic acid, conjugated with glucuronate, or conjugated with glycine to yield molecules that are excreted by the kidneys. The third of these conjugation processes is annotated here. It is the major route of ST catabolism and accounts for 20â65% of the products (Hutt et al, 1986). The conjugation proceeds in two steps. First, ST and ATP react with coenzyme A to form salicylate-CoA (ST-CoA), AMP, and pyrophosphate in a reaction catalyzed by xenobiotic/medium-chain fatty acid:CoA ligase (Vessey et al. 2003). Second, ST-CoA and glycine react to form salicyluric acid and Coenzyme A (Mawal and Qureshi 1994).
所含基因
8 个基因