逆行神经营养因子信号
中文名称
通路描述
神经营养因子-TRK 复合物可被内吞并进入信号囊泡，这些囊泡沿长距离从远端神经末梢到神经元细胞体逆行运输。此类逆行信号由神经营养因子-TRK 复合物调节，涉及生存、突触发生和维持适当神经连接。神经营养因子-TRK 复合物可能使用三种不同的内吞途径。虽然夹带蛋白介导的内吞似乎是最主要的内吞途径，但关于它是否也是逆行运输和信号的主导途径仍有争议。Pyncher 介导的内吞可能与此更为相关。此外，钙粘蛋白介导的内吞也可能在 NGF-TrkA 内吞中发挥作用。
TRK 的逆行运输依赖于微管：在逆行运输过程中，TRK 保持激活状态并与神经营养因子结合。当前观点反映在信号囊泡模型中。它是一种特殊的囊泡，含有与激活的 TRK 受体结合的配体 (NGF, BDNF)，以及激活的下游信号蛋白，由马达蛋白 (如驱动蛋白) 从神经末梢运输到远端细胞体，在那里受体触发信号级联反应。
TRK 的逆行运输依赖于微管：在逆行运输过程中，TRK 保持激活状态并与神经营养因子结合。当前观点反映在信号囊泡模型中。它是一种特殊的囊泡，含有与激活的 TRK 受体结合的配体 (NGF, BDNF)，以及激活的下游信号蛋白，由马达蛋白 (如驱动蛋白) 从神经末梢运输到远端细胞体，在那里受体触发信号级联反应。
英文描述
Retrograde neurotrophin signalling Neurotrophin-TRK complexes can be internalized and enter signalling vesicles, which travel retrogradely over long distances from distal nerve terminals to neuronal cell bodies. Such retrograde signalling by neurotrophin-TRK complexes regulates survival, synaptogenesis and maintenance of proper neural connectivity. The neurotrophin-TRK complex may use three distinct internalization pathways. Although Clathrin-mediated endocytosys appears to be the major internalization route, it is controversial whether it also represents the dominant pathway for retrograde transport and signalling. Pyncher-mediated endocytosis might be more relevant in this regard. Moreover, also caveolin-mediated endocytosis may play a role in NGF-TrkA internalization.
Retrograde transport of TRKs is microtubule-dependent: TRKs remain activated and bound to neurotrophins during retrograde transport. The current view is reflected in the signalling endosome model. It is a specialized vesicle containing ligand (NGF, BDNF) bound to its activated TRK receptor, together with activated downstream signalling proteins, transported by motor proteins (dyneins) from nerve terminals to remote cell bodies, where the receptors trigger signalling cascades.
Retrograde transport of TRKs is microtubule-dependent: TRKs remain activated and bound to neurotrophins during retrograde transport. The current view is reflected in the signalling endosome model. It is a specialized vesicle containing ligand (NGF, BDNF) bound to its activated TRK receptor, together with activated downstream signalling proteins, transported by motor proteins (dyneins) from nerve terminals to remote cell bodies, where the receptors trigger signalling cascades.
所含基因
14 个基因