自整合导致病毒 DNA 环
中文名称
通路描述
在该通路中，病毒整合机器使用病毒 DNA 上的一个位点作为整合靶点。这导致病毒 DNA 发生共价重排。形成的 DNA 不是整合的底物。有建议认为细胞 BAF 蛋白结合到病毒 DNA 上，通过包被和凝聚病毒 DNA 来减少自整合，从而使病毒 DNA 成为效率更低的整合靶点。
英文描述
Autointegration results in viral DNA circles In this pathway, the viral integration machinery uses a site within the viral DNA as an integration target. This results in a covalent rearrangment of the viral DNA. The resulting DNA forms are not substrates for integration.
It has been suggested that the cellular BAF protein binds to viral DNA and diminishes autointegration by coating and condensing the viral DNA, thereby making it a less efficient integration target.
It has been suggested that the cellular BAF protein binds to viral DNA and diminishes autointegration by coating and condensing the viral DNA, thereby making it a less efficient integration target.
所含基因
3 个基因