EGFR 信号传导中的 GRB2 事件
中文名称
通路描述
磷酸化的 EGFR 酪氨酸残基是 EGFR 信号传导下游效应体的结合位点。适配蛋白 GRB2 通过其 SH2 域结合到 EGFR C 尾部磷酸酪氨酸残基上。GRB2 与 SOS 结合，SOS 是 RAS 的鸟苷酸交换因子。GRB2 结合到磷酸化的 EGFR 导致 SOS 被招募到细胞膜，使其与 RAS 靠近。这种机制已被视为 RAS 激活的模型。
英文描述
GRB2 events in EGFR signaling Autophosphorylated EGFR tyrosine residues are docking sites for many downstream effectors in EGFR signaling. The adaptor protein GRB2 binds to phosphotyrosine residues in the C-tail of EGFR through its SH2 domain. GRB2 is constitutively associated with SOS, a guanine nucleotide exchange factor of RAS. GRB2 binding to phosphorylated EGFR results in the recruitment of SOS to the plasma membrane where it comes in proximity to RAS. This mechanism has been seen to be the model for RAS activation.
所含基因
9 个基因