DARPP-32 事件
中文名称
通路描述
DARPP-32 是多巴胺和蛋白激酶 A（PKA）在大脑皮层中的主要靶点。最新研究表明，DARPP-32 的磷酸化调节机制允许多巴胺感受性神经元通过多种神经递质、神经调质、神经肽和类固醇激素整合来自多个脑区的信息。PKA 或 PKG 的激活会导致 DARPP-32 在 Thr34 位点磷酸化，将其转化为蛋白磷酸酶 1（PP-1）的强效抑制剂。DARPP-32 还通过 Cdk5 在 Thr75 位点磷酸化，转化为 PKA 的抑制剂。因此，DARPP-32 是一种具有双重功能的蛋白质，既可以作为 PP-1 的抑制剂，也可以作为 PKA 的抑制剂。
英文描述
DARPP-32 events Dopamine- and cAMP-regulated phosphoprotein, Mr 32 kDa (DARPP-32), was identified as a major target for dopamine and protein kinase A (PKA) in striatum. Recent advances now indicate that regulation DARPP-32 phosphorylation provides a mechanism for integrating information arriving at dopaminoceptive neurons, in multiple brain regions, via a variety of neurotransmitters, neuromodulators, neuropeptides, and steroid hormones. Activation of PKA or PKG stimulates DARPP-32 phosphorylation at Thr34, converting DARPP-32 into a potent inhibitor of protein phosphatase-1 (PP-1). DARPP-32 is also phosphorylated at Thr75 by Cdk5, converting DARPP-32 into an inhibitor of PKA. Thus, DARPP-32 has the unique property of being a dual-function protein, acting either as an inhibitor of PP-1 or of PKA.
所含基因
23 个基因