GAB1 信号复合物
中文名称
通路描述
GAB1 通过 GRB2 间接招募到激活的 EGFR 上。GAB1 作为适配蛋白，通过招募 PI3K 调节亚基 PIK3R1（也称为 PI3Kp85）形成活性 PIK3，进而招募 PI3K 催化亚基 PIK3CA（也称为 PI3Kp110）。PIK3 与 EGFR、GRB2 和 GAB1 结合，催化 PIP2 的磷酸化并将其转化为 PIP3，从而激活 AKT 信号通路。
英文描述
GAB1 signalosome GAB1 is recruited to the activated EGFR indirectly, through GRB2. GAB1 acts as an adaptor protein that enables formation of an active PIK3, through recruitment of PIK3 regulatory subunit PIK3R1 (also known as PI3Kp85), which subsequently recruits PIK3 catalytic subunit PIK3CA (also known as PI3Kp110). PIK3, in complex with EGFR, GRB2 and GAB1, catalyzes phosphorylation of PIP2 and its conversion to PIP3, which leads to the activation of the AKT signaling.
所含基因
16 个基因