Vpu 介导的 CD4 降解
中文名称
通路描述
HIV-1 Vpu 蛋白通过招募类似 SCF 的泛素化复合物促进 CD4 受体的降解。Vpu 通过与 beta-TrCP 和 CD4 的胞质尾部相互作用，将 beta-TrCP 链接到 CD4 的 ER 膜上。随后，SCF 复合物中的 SKP1 组分被招募到 Vpu:beta-TrCP:CD4 上，促进泛素化和随后的蛋白酶体介导的 CD4 降解（参见 Li 等人，2005）。Vpu 还被证明可以增加感染细胞的后代病毒分泌。虽然 Vpu 在此过程中的确切作用尚不清楚，但它可能影响离子导电膜孔的形成，并干扰 TASK-1，这是一种对酸敏感的 K+ 通道，在某些细胞中抑制病毒释放（参见 Li 等人，2005）。
英文描述
Vpu mediated degradation of CD4 The HIV-1 Vpu protein promotes the degradation of the CD4 receptor by recruiting an SCF like ubiquitination complex that promotes CD4 degradation. Vpu links beta-TrCP to CD4 at the ER membrane through interactions with beta-TrCP and the cytoplasmic tail of CD4. The SKP1 component of the SCF complex is then recruited to the Vpu:beta-TrCP:CD4 promoting ubiquitination and subsequent proteasome-mediated degradation of CD4 (reviewed in Li et al., 2005). Vpu has also been shown to also increases progeny virus secretion from infected cells. Although the precise role of Vpu in this process is not yet known, it may affect ion conductive membrane pore formation and/or interference with TASK-1, an acid-sensitive K+ channel that inhibits virion release in some cells (see references in Li et al., 2005).
所含基因
39 个基因