5-羟色胺神经递质释放循环
中文名称
通路描述
5-羟色胺在中枢神经系统的5-羟色胺能神经元和胃肠道的嗜铬细胞中合成。5-羟色胺被加载到由氯仿素修饰的单胺转运囊泡中。囊泡在膜电位变化后停靠、激活，随后在电压门控钙通道和多种蛋白对细胞内Ca2+浓度增加的反应下融合并释放到突触间隙。
英文描述
Serotonin Neurotransmitter Release Cycle Serotonin is synthesized in the serotonergic neurons in the central nervous system and the enterochrommaffin cells of the gastroinetstinal system. Serotonin is loaded into the clathrin sculpted monoamine transport vesicles. The vesicles are docked, primed and release after the change in the membrane potential that activates voltage gated calcium channels and the reponse by several proetins to the changes in intracellular Ca2+ increase leads to fusion of the vesicle and release of serotonin into the synapse.
所含基因
17 个基因