Nef介导的CD8下调
中文名称
通路描述
人类免疫缺陷病毒（HIV）的Nef是一种膜相关蛋白，降低感染细胞上CD4、CD28和主要组织相容性复合体（MHC）I类的表面表达。Nef还通过加速内吞作用显著下调CD8αβ受体β链的表面表达，而CD8α链的表达受影响较小。对CD8β链胞质尾部的突变分析表明，FMK氨基酸基序对于Nef诱导的内吞作用至关重要。尽管CD8β链的内吞作用与影响CD4下调的相同突变无关，但表明存在共同的分子相互作用。CD8β链下调的能力在HIV-1、HIV-2和猴免疫缺陷病毒SIVmac239 Nef中得以保留，并需要完整的AP-2复合物。
英文描述
Nef Mediated CD8 Down-regulation Human immunodeficiency virus (HIV) Nef is a membrane-associated protein decreasing surface expression of CD4, CD28, and major histocompatibility complex class I on infected cells. Nef also strongly down-modulates surface expression of the beta-chain of the CD8alphabeta receptor by accelerated endocytosis, while CD8 alpha-chain expression is less affected. Mutational analysis of the cytoplasmic tail of the CD8 beta-chain indicates that an FMK amino acid motif is critical for the Nef-induced endocytosis. Although independent of CD4, endocytosis of the CD8 beta-chain is abrogated by the same mutations in Nef that affect CD4 down-regulation, suggesting common molecular interactions. The ability to down-regulate the human CD8 beta-chain was conserved in HIV-1, HIV-2, and simian immunodeficiency virus SIVmac239 Nef and required an intact AP-2 complex.
所含基因
7 个基因