胞质病原体相关 DNA 传感器
中文名称
通路描述
胞质中病原体相关 DNA 的存在诱导 I 型干扰素的产生。已涉及多种细胞内受体，包括 DNA 依赖的干扰素调节因子 (DAI，也称为 Z-DNA 结合蛋白 1, ZBP1)、黑色素瘤缺失 2 (AIM2)、RNA 聚合酶 III (Pol III)、干扰素诱导蛋白 IFI16、富含亮氨酸的重复飞行蛋白 1 (LRRFIP1)、DEAH 盒型解旋酶 (DHX9 和 DHX36)、DEAD 盒型解旋酶 DDX41、减数分裂重组 11 同源物 A (MRE11)、DNA 依赖的蛋白激酶 (DNA-PK)、环 GMP-AMP 合酶 (cGAS) 和干扰素基因刺激物 (STING)。检测胞质 DNA 需要多个且可能冗余的传感器，导致转录因子 NF-kappaB 和 TBK1 介导的转录因子 IRF3 磷酸化。胞质 DNA 还激活 caspase-1 依赖性促炎细胞因子白细胞介素 IL-1beta 和 IL-18 的成熟。该通路由 AIM2 介导。
英文描述
Cytosolic sensors of pathogen-associated DNA Presence of pathogen-associated DNA in cytosol induces type I IFN production. Several intracellular receptors have been implicated to some degree. These include DNA-dependent activator of interferon (IFN)-regulatory factors (DAI) (also called Z-DNA-binding protein 1, ZBP1), absent in melanoma 2 (AIM2), RNA polymerase III (Pol III), IFN-inducible protein IFI16, leucine-rich repeat flightless interacting protein-1 (LRRFIP1), DEAH-box helicases (DHX9 and DHX36), DEAD-box helicase DDX41, meiotic recombination 11 homolog A (MRE11), DNA-dependent protein kinase (DNA-PK), cyclic GMP-AMP synthase (cGAS) and stimulator of interferon genes (STING).Detection of cytosolic DNA requires multiple and possibly redundant sensors leading to activation of the transcription factor NF-kappaB and TBK1-mediated phosphorylation of the transcription factor IRF3. Cytosolic DNA also activates caspase-1-dependent maturation of the pro-inflammatory cytokines interleukin IL-1beta and IL-18. This pathway is mediated by AIM2.
所含基因
23 个基因