FGFR3 激活点突变体的信号传导
中文名称
通路描述
激活的 FGFR3 点突变存在于胞外配体结合结构域、跨膜区域和酪氨酸激酶结构域中，被认为是导致受体配体独立激活的结果 (Webster and Donoghue, 1996; Wenbster, 1997)。这些突变虽然在最初是在常染色体骨骼疾病背景下被表征的，但现在已被识别在一系列癌症中，包括膀胱、宫颈、乳腺癌、前列腺、头颈部和多发性骨髓瘤 (综述 Wesche, 2011)。
英文描述
Signaling by activated point mutants of FGFR3 Activating point mutations in FGFR3 are found in the extracellular ligand-binding domain, the transmembrane region and the tyrosine kinase domain and are believed to result in ligand-independent activation of the receptor (Webster and Donoghue, 1996; Wenbster, 1997). These mutations, although initially characterized in the context of autosomal skeletal disorders, are now being identified in a range of cancers including bladder, cervical, breast, prostate, head and neck, and multiple myeloma (reviewed in Wesche, 2011).
所含基因
8 个基因