下游信号转导
中文名称
通路描述
PDGF受体上的自磷酸化位点为下游含有SH2结构域的信号转导分子提供结合位点。SH2结构域是一个约100个氨基酸的保守基序，可结合磷酸化的酪氨酸残基。这些下游分子在与受体激酶结合或被其磷酸化后会被激活。一些下游分子本身也是酶，如磷脂酰肌醇3'-激酶（PI3K）、磷脂酶C（PLC-gamma）、Src家族酪氨酸激酶、酪氨酸磷酸酶SHP2以及Ras的GTP酶激活蛋白（GAP）。其他如Grb2是连接受体与下游催化分子的适配分子。
英文描述
Downstream signal transduction The role of autophosphorylation sites on PDGF receptors are to provide docking sites for downstream signal transduction molecules which contain SH2 domains. The SH2 domain is a conserved motif of around 100 amino acids that can bind a phosphorylated tyrosine residue. These downstream molecules are activated upon binding to, or phosphorylated by, the receptor kinases intrinsic to PDGF receptors.
Some of the dowstream molecules are themselves enzymes, such as phosphatidylinositol 3'-kinase (PI3K), phospholipase C (PLC-gamma), the Src family of tyrosine kinases, the tyrosine phosphatase SHP2, and a GTPase activating protein (GAP) for Ras. Others such as Grb2 are adaptor molecules which link the receptor with downstream catalytic molecules.
Some of the dowstream molecules are themselves enzymes, such as phosphatidylinositol 3'-kinase (PI3K), phospholipase C (PLC-gamma), the Src family of tyrosine kinases, the tyrosine phosphatase SHP2, and a GTPase activating protein (GAP) for Ras. Others such as Grb2 are adaptor molecules which link the receptor with downstream catalytic molecules.
所含基因
25 个基因