PDGF的信号转导
中文名称
通路描述
血小板衍生生长因子（PDGF）是连接组织细胞（如成纤维细胞和平滑肌细胞）以及其他细胞（如毛细血管内皮细胞和神经元）生长和运动的有效刺激剂。PDGF生长因子家族由四个不同基因编码的四种不同多肽链组成。经典PDGF链包括PDGF-A和PDGF-B，以及最近发现的PDGF-C和PDGF-D。四种PDGF链通过同源或异源二聚化以二硫键结合形成二聚体，迄今为止已描述出五种不同的二聚体异构体：PDGF-AA、PDGF-AB、PDGF-BB、PDGF-CC和PDGF-DD。值得注意的是，尚未发现涉及PDGF-C和PDGF-D链的异二聚体。PDGF通过结合并激活两种蛋白酪氨酸激酶（PTK）受体（α和β）发挥作用。这些受体二聚化并发生自磷酸化。随后，磷酸化位点吸引下游效应分子，将信号传导至细胞内。
英文描述
Signaling by PDGF Platelet-derived Growth Factor (PDGF) is a potent stimulator of growth and motility of connective tissue cells such as fibroblasts and smooth muscle cells as well as other cells such as capillary endothelial cells and neurons.The PDGF family of growth factors is composed of four different polypeptide chains encoded by four different genes. The classical PDGF chains, PDGF-A and PDGF-B, and more recently discovered PDGF-C and PDGF-D. The four PDGF chains assemble into disulphide-bonded dimers via homo- or heterodimerization, and five different dimeric isoforms have been described so far; PDGF-AA, PDGF-AB, PDGF-BB, PDGF-CC and PDGF-DD. It is notable that no heterodimers involving PDGF-C and PDGF-D chains have been described. PDGF exerts its effects by binding to, and activating, two protein tyrosine kinase (PTK) receptors, alpha and beta. These receptors dimerize and undergo autophosphorylation. The phosphorylation sites then attract downstream effectors to transduct the signal into the cell.
所含基因
32 个基因