通过 RIT 和 RIN 的信号转导至 p38
中文名称
通路描述
RIT 和 RIN 是两种小 GTP 结合蛋白，其序列与 RAS 共享超过 50% 的同源性，包括高度保守的核心效应子结构域。与 RAS 不同，RIT 和 RIN 的 C 末端缺乏与 RAS 蛋白与质膜结合所需的典型泛素化基序（CAAX, XXCC 或 CXC）。RIT 在所有组织中表达，而 RIN 是神经元特异性的。它们具有相似的信号特性，并通过未知的交换因子由 NGF 激活。它们向 ERKs 和 p38 MAP 激酶信号。它们主要通过 BRAF-MEK 激酶级联导致 p38 激活。
英文描述
Signalling to p38 via RIT and RIN RIT and RIN are two small guanine nucleotide binding proteins that share more than 50% sequence identity with RAS, including highly conserved core effector domains. Unlike RAS, the C termini of RIT and RIN lack a typical prenylation motif (CAAX, XXCC, or CXC) required for the association of RAS proteins with the plasma membrane. RIT is expressed in all tissues, whereas RIN is neuron-specific. They have similar signalling properties and are activated by NGF through unknown exchange factors. They signal to ERKs and p38 MAP kinase. They mainly lead to p38 activation via the BRAF-MEK kinase cascade.
所含基因
5 个基因