连接素聚合成连接子
中文名称
通路描述
连接素聚合成连接子的机制已得到充分表征。可以形成两种不同类型的连接子。包含六个相同连接素分子的连接子称为同源连接子，而包含至少两种不同连接素分子的连接子称为异源连接子。构成异源连接子的连接素分子似乎只属于一个亚组（α或β）；尚未观察到同时含有α和β亚基的异源连接子。事实上，四个氨基酸位点内的内在信号似乎赋予α组和β组某些连接素不同的理化特性（Lagr et al., 2003）。这些内在信号是Cx特异性的（见 Gemel et al., 2006）。因此，还需要额外的未知信号来调节连接素的兼容性以及异源寡聚化。
英文描述
Oligomerization of connexins into connexons The mechanism of connexin assembly into connexons has been well characterized. Two different types of connexons can be formed. A connexon containing six identical connexin molecules is referred to as an homomeric connexon, while a connexon containing at least two different connexin molecules is referred to as an heteromeric connexon. The connexin molecules making up an heteromeric connexon appear to belong to only one subgroup (alpha or beta); heteromeric connexons containing both alpha and beta subunits have not yet been observed. Indeed, an intrinsic signal in four amino acid positions appears to confer different physicochemical characteristics to certain connexins in the alpha and beta groups (Lagr et al., 2003). These intrinsic signals are Cx specific, however (see Gemel et al., 2006). Therefore, additional yet unknown signals are required to regulate connexin compatibility and hetero-oligomerization.
The identification of the subcellular location at which gap junction assembly occurs has proven difficult. One explanation for this difficulty may be that the location of oligomerization for each connexon varies depending upon Cx type or cell type. Oligomerization has been observed after ER membrane insertion (Cx43, Cx32, Cx26) (Falk et al., 1997; Ahmad et al., 1999; Ahmad and Evans, 2002), in the ER-Golgi-intermediate compartment (ERGIC) (Cx32) (Diez et al. 1999) and inside the trans-Goligi network (Cx43) (Musil and Goodenough, 1993).
The identification of the subcellular location at which gap junction assembly occurs has proven difficult. One explanation for this difficulty may be that the location of oligomerization for each connexon varies depending upon Cx type or cell type. Oligomerization has been observed after ER membrane insertion (Cx43, Cx32, Cx26) (Falk et al., 1997; Ahmad et al., 1999; Ahmad and Evans, 2002), in the ER-Golgi-intermediate compartment (ERGIC) (Cx32) (Diez et al. 1999) and inside the trans-Goligi network (Cx43) (Musil and Goodenough, 1993).
所含基因
3 个基因