连接素沿分泌途径的运输
中文名称
通路描述
连接素沿分泌途径运输：ER -> ERGIC -> 高尔基体 -> 高尔基体网络 (TGN) -> 质膜 (PM)。所有连接素聚合成六聚体连接子。聚化位点因Cx亚型或细胞类型而异（见 Koval et al., 2006）。连接素的聚化已在 ER 膜插入 (Cx32)、ER-高尔基体中间隔区 (ERGIC) (Cx32) 和高尔基体网络内部 (Cx43) 观察到（Falk et al. 1997; Ahmad et al. 1999; Musil and Goodenough 1993; Diez et al. 1999）。
英文描述
Transport of connexins along the secretory pathway Connexins follow the classical secretory transport route from the ER to the plasma membrane: ER -> ERGIC -> Golgi -> TGN (Trans Golgi Network) -> PM (Plasma Membrane). All connexins assemble or oligomerize into hexameric connexons. The site of assembly varies and depends on Cx isoform, or cell type (see Koval et al., 2006).
Oligomerization of connexins has been observed during ER membrane insertion (Cx32), just after exit from the ER, in the ER-Golgi-intermediate compartment (Cx26) and inside the Trans-Golgi Network (Cx43) (Falk et al. 1997; Ahmad et al. 1999; Musil and Goodenough 1993; Diez et al. 1999).
Oligomerization of connexins has been observed during ER membrane insertion (Cx32), just after exit from the ER, in the ER-Golgi-intermediate compartment (Cx26) and inside the Trans-Golgi Network (Cx43) (Falk et al. 1997; Ahmad et al. 1999; Musil and Goodenough 1993; Diez et al. 1999).
所含基因
3 个基因