间隙连接聚化
中文名称
通路描述
间隙连接的聚化涉及（1）在内质网膜上合成连接素多肽，（2）聚合成同源和异源间隙连接连接子（半通道），（3）穿过高尔基体堆叠，（4）在内质网膜内储存，（5）沿微管运输，（6）连接子插入质膜，（7）质膜内连接子在侧向扩散，（8）单个间隙连接通道聚集形成斑块，（9）通过结合基于 Cx43 的间隙连接稳定周缘微管正极末端（见 Segretain and Falk, 2004。）
英文描述
Gap junction assembly The assembly of gap junctions involves (1) synthesis of connexin polypeptides at endoplasmic reticulum membranes, (2) oligomerization into homomeric- and heteromeric gap junction connexons (hemi-channels), (3) passage through the Golgi stacks, (4) intracellular storage within Trans Golgi membranes, (5) trafficking along microtubules, (6) insertion of connexons into the plasma membrane, (7) lateral diffusion of connexons in the plasma membrane, (8) aggregation of individual gap junction channels into plaques, and (9) stabilization of peripheral microtubule plus-ends by binding to Cx43-based gap junctions (see Segretain and Falk, 2004.)
所含基因
37 个基因