vRNA 合成
中文名称
通路描述
从 cRNA 模板合成全长负链病毒 RNA 被认为遵循与从 vRNA 模板合成 cRNA 相同的原理。与病毒核蛋白 (NP) 蛋白结合的 cRNA 作为模板被三聚体病毒聚合酶 (Pritlove, 1995; Vreede, 2004; Crow, 2004) 使用，新合成的 vRNA 分子立即与 NP 分子结合形成核糖核蛋白复合物 (Vreede, 2004)。有证据表明，含有 vRNA 的 vRNP 的产生发生在核基质和核浆中 (Takizawa, 2006)。
英文描述
vRNA Synthesis The synthesis of full-length negative strand viral RNA from a cRNA template is believed to follow the same principles as the synthesis of cRNA from a vRNA template. The cRNA, complexed with viral nucleocapsid (NP) protein, is used as template by the trimeric viral polymerase (Pritlove, 1995; Vreede, 2004; Crow, 2004), and newly synthesized vRNA molecules are immediately packaged with NP molecules to form ribonucleoprotein complexes (Vreede, 2004). There is some evidence that the production of vRNA-containing vRNP occurs in the nuclear matrix as well as the nucleoplasm (Takizawa, 2006).
所含基因
5 个基因