cRNA 合成
中文名称
通路描述
合成全长互补病毒 RNA (cRNA) 需要 vRNA 转录在无宿主细胞甲基化 RNA 帽作为引物的帮助下开始，并且向 vRNA 模板的 5' 端延伸，不出现亚末端 poly-U 序列的停顿。游离病毒 NP 蛋白似乎在这两种 cRNA 合成的特征中起着中心作用，尽管其作用机制尚不清楚 (Shapiro, 1988; Medcalf, 1999; Mullin, 2004)。
英文描述
cRNA Synthesis Synthesis of full length complementary viral RNA (cRNA) requires that vRNA transcription initiates without the help of a host cell methyl RNA cap as a primer (Crow, 2004; Vreede, 2004; Deng, 2006), and that it proceeds to the 5' end of the vRNA template without stuttering on the sub-terminal poly-U sequence. Free viral NP protein appears to play a central role in enabling both of these features of cRNA synthesis, although the molecular details of its role remain unclear (Shapiro, 1988; Medcalf, 1999; Mullin, 2004).
所含基因
4 个基因