vRNP 组装
中文名称
通路描述
对于每种 8 个基因片段，病毒核糖核蛋白 (vRNP) 由与核蛋白 (NP) 结合的病毒负链 RNA (vRNA) 片段和三聚体流感聚合酶 (PB1, PB2 和 PA) 组成，在细胞核中组装 (Braam, 1983; Jones, 1986; Cros, 2003; 综述 Buolo, 2006)。vRNP 在三种模式发挥作用 (综述 Mikulasova, 2000; Neumann, 2004)：(1) 转录，使用含有帽子的细胞 mRNA 5' 端作为引物合成病毒信使 RNA 从 vRNA 模板；(2) 复制，产生正链互补 RNA (cRNA) 并随后合成 vRNA，两者均与 NP 和三聚体聚合酶结合；或 (3) vRNP 从细胞核导出到细胞质，并在细胞膜上组装病毒颗粒。
英文描述
vRNP Assembly For each of eight gene segments, a viral ribonucleoprotein (vRNP), containing a viral negative-sense RNA (vRNA) segment complexed with nucleoprotein (NP) and the trimeric influenza polymerase (PB1, PB2, and PA), is assembled in the nucleus (Braam, 1983; Jones, 1986; Cros, 2003; reviewed in Buolo, 2006). The vRNP functions in three modes (reviewed in Mikulasova, 2000; Neumann, 2004): (1) transcription, which synthesizes viral messenger RNA from the vRNA template using as primers 5' ends of cellular mRNAs containing the cap; (2) replication, which produces positive-sense complementary RNA (cRNA) and subsequently vRNA, both complexed with NP and the trimeric polymerase; or (3), the vRNP is exported from the nucleus into the cytoplasm and is incorporated into assembling virions at the plasma membrane.
所含基因
6 个基因