p75NTR的受控蛋白水解
中文名称
通路描述
p75NTR经历受控膜内蛋白水解（RIP）过程，类似于其他跨膜蛋白，如NOTCH、β-淀粉样前蛋白（APP）和ERBB4。每种蛋白均接受两次连续切割。第一次切割发生在蛋白的细胞外部分，由金属蛋白酶α分泌酶介导，导致细胞外结构域脱落。第二次切割发生在膜内区域，由γ分泌酶介导，导致胞内结构域（ICD）和一个小肽的释放。ICD常转运至细胞核，在某些情况下（如NOTCH），已被发现作为转录调节因子。p75NTR的α和γ分泌酶介导的切割似乎受神经生长因子（NGF）或脑源性神经营养因子（BDNF）与TRKA或TRKB结合所调节。p75NTR的加工在反应性谷氨酸能谷状细胞（cerebellar granule neurons）中由MAG介导。
英文描述
Regulated proteolysis of p75NTR p75NTR undergoes a process of regulated intramembrane proteolysis (RIP) similar to other transmembrane proteins such as NOTCH, beta-amyloid precursor protein (APP), and ERBB4. Each of these proteins is subjected to two sequential cleavages. The first one occurs in the extracellular part of the protein and is mediated by the metalloproteinase alpha-secretase which causes shedding of the extracellular domain. The second cleavage occurs in the intramembrane region and is mediated by gamma-secretase and causes release of the intracellular domain, ICD, and of a small peptide. The ICD often traffics to the nucleus and, in some instances (e.g. NOTCH), was found to act as transcriptional regulator. Whether the p75NTR ICD does translocate to the nucleus to regulate gene expression in a way similar to the NOTCH receptor remains to be seen. The alpha- and gamma-secretase mediated cleavage of p75 appears to be regulated by neurotrophin (NGF, BDNF) binding to TRKA or TRKB. p75NTR processing also occurs in response to MAG in cerebellar granule neurons.
所含基因
11 个基因