类固醇激素生物合成
中文名称
通路描述
醛固酮是主要的人类类固醇激素，在肾上腺皮质束状带中从孕烯醇酮合成。孕烯醇酮在两个反应中转化为孕酮，均由3β-羟化酶/异构酶催化。孕酮由CYP21A2羟基化形成去氧皮质酮，后者在三反应序列中由CYP11B2催化转化为醛固酮（Payne and Hales 2004）。
英文描述
Mineralocorticoid biosynthesis Aldosterone, the major human mineralocorticoid, is synthesized in the zona glomerulosa of the adrenal cortex from pregnenolone. Pregnenolone is converted to progesterone in two reactions, both catalyzed by 3-beta-hydroxysteroid dehydrogenase/isomerase. Progesterone is hydroxylated by CYP21A2 to form deoxycorticosterone, which in turn is converted to aldosterone in a three-reaction sequence catalyzed by CYP11B2 (Payne and Hales 2004).
所含基因
6 个基因