类固醇激素的生物合成
中文名称
通路描述
皮质醇是人体主要的类固醇激素，在肾上腺皮质致密带中从孕烯醇酮合成。孕烯醇酮经过两个反应转化为17α-羟孕酮，这两个反应均由3β-羟化酶/异构酶催化。17α-羟孕酮被CYP21A2羟化形成11-去氧皮质醇，后者再被CYP11B1转化为皮质醇。活性类固醇激素皮质醇向无活性皮质酮的转化在许多组织中发生，特别是在肝脏中（Payne and Hales 2004）。
英文描述
Glucocorticoid biosynthesis Cortisol, the major human glucocorticoid, is synthesized in the zona fasciculata of the adrenal cortex from pregnenolone. Pregnenolone is converted to 17alpha-hydoxyprogesterone in two reactions, both catalyzed by 3-beta-hydroxysteroid dehydrogenase/isomerase. 17Alpha-hydroxyprogesterone is hydroxylated by CYP21A2 to form 11-deoxycortisol, which in turn is converted to cortisol by CYP11B1. The conversion of the active steroid hormone, cortisol, to inactive cortisone occurs in many tissues, notably the liver (Payne and Hales 2004).
所含基因
10 个基因