神经皮素与VEGF和VEGFR的相互作用
中文名称
通路描述
细胞膜附着的神经皮素受体NRP-1和-NRP-2结合一些VEGF蛋白并与VEGF受体蛋白结合。NRP-1结合VEGF-A165、-B和PLGF-2；NRP-2也结合VEGF-A165和PLGF-2，以及VEGF-A145和-C。神经皮素受体似乎作为VEGF受体的辅因子，增加其对特定VEGF配体的亲和力，尽管这种功能在体内的作用尚不清楚（Neufeld et al. 2002）。
英文描述
Neuropilin interactions with VEGF and VEGFR The plasma membrane-associated Neuropilin receptors NRP-1 and -2 bind some of the VEGF proteins and associate with VEGF receptor proteins. NRP-1 binds VEGF-A165, -B, and PLGF-2; NRP-2 also binds VEGF-A165 and PLGF-2, as well as VEGF-A145 and -C. The Neuropilin receptors appear to act as cofactors for the VEGF receptors, increasing their affinities for specific VEGF ligands, although the importance of this function in vivo remains unclear (Neufeld et al. 2002).
所含基因
4 个基因