VEGF配体 - 受体相互作用
中文名称
通路描述
VEGF家族由七个基因编码（VEGF-A, B, C, D, E: PLGF (胎盘生长因子)-1, 2）。六个VEGF-A蛋白异构体，含有121、145、165、183、189和206个氨基酸残基，以及两个VEGF-B异构体（167和186个残基），由交替剪接mRNA指定。这些蛋白的活性形式是同源二聚体。三种VEGF酪氨酸激酶受体VEGFR-1、VEGFR-2和VEGFR-3对这些配体的特异性在图中显示（Hicklin and Ellis 2005）。所有VEGF-A异构体都同时结合VEGFR-1和VEGFR-2；PLGF-1和-2以及VEGF-B异构体仅结合VEGFR-1；VEGF-E结合VEGFR-2；而VEGF-C和-D同时结合VEGFR-2和-3。VEGF-D经历一系列复杂的翻译后修饰，导致具有增加对VEGFR-3和VEGFR-2活性的分泌形式。
英文描述
VEGF ligand-receptor interactions The VEGF family is encoded by seven genes (VEGF-A, B, C, D, E: PLGF (Placenta Growth Factor)-1, 2). Six isoforms of VEGF-A protein, containing 121, 145, 165, 183, 189, and 206 amino acid residues, and two isoforms of VEGF-B (167 and 186 residues) are specified by alternatively spliced mRNAs. The active form of each of these proteins is a homodimer.
The specificities of the three VEGF tyrosine kinase receptors, VEGFR-1, VEGFR-2 and VEGFR-3, for these ligands are shown in the figure (Hicklin and Ellis 2005). All VEGF-A isoforms bind both VEGFR-1 and VEGFR-2; PLGF-1 and -2, and VEGF-B isoforms bind only VEGFR-1; VEGF-E binds VEGFR-2; and VEGF-C and -D bind both VEGFR-2 and -3. VEGF-D undergoes a complex series of post-translational modifications that results in secreted forms with increased activity toward VEGFR-3 and VEGFR-2.
Two co-receptor proteins in the cell membrane, neuropilin (NRP)-1 and NRP-2, interact with VEGFR proteins to increase the affinity of the latter for their ligands (Neufeld et al.,2002). They differ from VEGFR proteins in not having intracellular signaling domains.
The specificities of the three VEGF tyrosine kinase receptors, VEGFR-1, VEGFR-2 and VEGFR-3, for these ligands are shown in the figure (Hicklin and Ellis 2005). All VEGF-A isoforms bind both VEGFR-1 and VEGFR-2; PLGF-1 and -2, and VEGF-B isoforms bind only VEGFR-1; VEGF-E binds VEGFR-2; and VEGF-C and -D bind both VEGFR-2 and -3. VEGF-D undergoes a complex series of post-translational modifications that results in secreted forms with increased activity toward VEGFR-3 and VEGFR-2.
Two co-receptor proteins in the cell membrane, neuropilin (NRP)-1 and NRP-2, interact with VEGFR proteins to increase the affinity of the latter for their ligands (Neufeld et al.,2002). They differ from VEGFR proteins in not having intracellular signaling domains.
所含基因
5 个基因