环状间隙连接的形成
中文名称
通路描述
间隙连接斑块的内吞作用及细胞通讯的破坏需要 Cx 分子相互作用的重组。包括 Dab-2、AP-2、Dynamin 和肌球蛋白 VI 在内的蛋白质与间隙连接斑块结合，允许斑块在夹带蛋白结合后内吞（Piehl et al., 2007）。迄今为止，已描述两种类型的环状间隙连接。第一种是类似小囊泡的结构，允许间隙连接斑块更新而不影响功能（Jordan et al., 2001）。第二种是大型环状结构，主要由两个相邻细胞的连接斑块组成（Jordan et al., 2001; Segretain et al., 2004）。
英文描述
Formation of annular gap junctions Gap junction plaque internalization and the disruption cell communication requires a reorganization of Cx molecular interactions. Proteins including Dab-2, AP-2, Dynamin and Myosin VI associate with gap junction plaques permitting the internalisation of plaques after clathrin association (Piehl et al., 2007). Until now, two kinds of annular gap junctions have been described. The first is a small vesicle like structure which permits gap junction plaque renewal without arrest of functionality (Jordan et al., 2001). The second is a large annular structure, composed primarily of the junctional plaques of two adjacent cells (Jordan et al., 2001; Segretain et al., 2004).
所含基因
11 个基因