辅酶 A 生物合成
中文名称
通路描述
辅酶 A (CoA) 是一种普遍存在的辅因子，作为酰基载体在多种过程中发挥作用，包括脂肪酸代谢和 TCA 循环 (Lipmann 1953)。它由维生素泛酸在五个反应中合成 (Daugherty et al. 2002; Leonardi et al. 2005; Robishaw and Neely 1985)。这些反应均在细胞质或线粒体膜间隙中进行 (Leonardi et al. 2005)。最近描述的一种转运蛋白似乎介导辅酶 A 向线粒体基质中的摄取 (Prohl et al. 2001)。
英文描述
Coenzyme A biosynthesis Coenzyme A (CoA) is a ubiquitous cofactor that functions as an acyl group carrier in diverse processes including fatty acid metabolism and the TCA cycle (Lipmann 1953). It is synthesized from the vitamin pantothenate in a sequence of five reactions (Daugherty et al. 2002; Leonardi et al. 2005; Robishaw and Neely 1985). These reactions all occur in the cytosol or the mitochondrial intermembrane space (Leonardi et al. 2005). A recently described transport protein appears to mediate the uptake of Coenzyme A into the mitochondrial matrix (Prohl et al. 2001).
所含基因
7 个基因