糖胺聚糖 - 蛋白质连接区域生物合成
中文名称
通路描述
糖胺聚糖 - 蛋白质连接区域生物合成以核心蛋白上特定丝氨酸残基羟基的添加起始，形成四糖连接序列。随后添加两个半乳糖和一个葡萄糖醛酸基团完成连接序列。在此之后，下一个六氨基糖的添加至关重要，因为它决定了形成哪种糖胺聚糖（Lamberg & Stoolmiller 1974, Pavao et al. 2006）。
英文描述
Glycosaminoglycan-protein linkage region biosynthesis The biosynthesis of dermatan sulfate/chondroitin sulfate and heparin/heparan sulfate glycosaminoglycans (GAGs) starts with the formation of a tetrasaccharide linker sequence to the core protein. The first step is the addition of xylose to the hydroxy group of specific serine residues on the core protein. Subsequent additions of two galactoses and a glucuronide moiety completes the linker sequence. From here, the next hexosamine addition is critical as it determines which GAG is formed (Lamberg & Stoolmiller 1974, Pavao et al. 2006).
所含基因
29 个基因