PI3K/AKT 激活
中文名称
通路描述
PI3K/AKT 信号传导是神经元存活的主要调节者。它通过影响细胞质细胞死亡机器并调节参与细胞死亡和存活基因的表达来阻止细胞死亡。此外，它还可能通过代谢途径调节细胞存活。PI3K/AKT 通路还影响轴突直径和分支（Marcus et al, 2002），并调节小 G 蛋白如 RhoA（Vanhaesebroeck, B 和 Waterman, MD, 1999），这些蛋白控制 F-肌动蛋白细胞骨架的行为。此外，通过与 TOR 通路的连接，它促进部分 mRNAs 的翻译。
英文描述
PI3K/AKT activation PI3K/AKT signalling is a major regulator of neuron survival. It blocks cell death by both impinging on the cytoplasmic cell death machinery and by regulating the expression of genes involved in cell death and survival. In addition, it may also use metabolic pathways to regulate cell survival.The PI3K/AKT pathway also affects axon diameter and branching (Marcus et al, 2002) and regulates small G proteins like RhoA (Vanhaesebroeck, B and Waterman, MD, 1999), which control the behaviour of the F-actin cytoskeleton. Moreover, through its connection with the TOR pathway, it promotes translation of a subset of mRNAs.
所含基因
9 个基因