FGFR2 扩增突变体的信号传导
中文名称
通路描述
FGFR2 扩增已在 10% 的胃癌中被鉴定，与预后差的弥漫性癌症相关 (Hattori, 1996; Ueda, 1999; Shin, 2000; Kunii, 2008)，并在约 1% 的乳腺癌中观察到 (Turner, 2010; Tannheimer, 2000)。FGFR2 扩增常与 C 端外显子的缺失发生，导致受体表达出内吞和降解抵抗的形式 (Takeda, 1999; Cha, 2008, 2009)。扩增不影响受体的固有激酶活性。过表达 FGFR2 的信号传导也显示出对配体独立且对 FGFR 抑制剂敏感的证据 (Lorenzi, 1997; Takeda, 1999; Cha, 2009)。
英文描述
Signaling by FGFR2 amplification mutants FGFR2 amplifications have been identified in 10% of gastric cancers, where they are associated with poor prognosis diffuse cancers (Hattori, 1996; Ueda, 1999; Shin, 2000; Kunii, 2008) , and in ~1% of breast cancers (Turner, 2010; Tannheimer, 2000). FGFR2 amplification often occur in conjunction with deletions of C-terminal exons, resulting in expression of a internalization- and degradation-resistant form of the receptor (Takeda, 1999; Cha, 2008, 2009). Amplification affects signaling without altering the intrinsic kinase activity of the receptor. Signaling through overexpressed FGFR2 also shows evidence of being ligand-independent and sensitive to FGFR inhibitors (Lorenzi, 1997; Takeda, 1999; Cha, 2009).
所含基因
1 个基因