HS-GAG 降解
中文名称
通路描述
糖蛋白的溶酶体降解是糖基化细胞稳态的一部分 (Winchester 2005)。以下步骤描述了从肝素硫酸蛋白聚糖 (HSPGs) 中切割肝素硫酸酯/肝素的过程及其降解。为了避免糖胺聚糖片段在溶酶体中积累导致溶酶体贮积病，必须完全降解糖蛋白。糖蛋白核心蛋白的解聚在此未示，但糖蛋白核心蛋白的解聚步骤在此未示，因为它们与此处描述的主要步骤重复。
英文描述
HS-GAG degradation Lysosomal degradation of glycoproteins is part of the cellular homeostasis of glycosylation (Winchester 2005). The steps outlined below describe the cleavage of heparan sulfate/heparin from heparan sulfate proteoglycans (HSPGs) and its degradation. Complete degradation of glycoproteins is required to avoid build up of glycosaminoglycan fragments which can cause lysosomal storage diseases. The proteolysis of the core protein of the glycoprotein is not shown here.
所含基因
10 个基因