ERKs 被抑制
中文名称
通路描述
MAP 激酶家族蛋白激酶磷酸酶（MKPs）通过脱磷酸化位于 MAP 激酶激活环中的签名序列 -pTXpY- 中的丝氨酸/苏氨酸和/或酪氨酸残基来抑制 MAP 激酶。MKPs 根据对脱磷酸化的偏好分为三大类：酪氨酸特异性、丝氨酸/苏氨酸特异性和两者兼有（双重特异性磷酸酶或 DUSPs）。酪氨酸特异性 MKP 包括 PTP-SL、STEP 和 HePTP，丝氨酸/苏氨酸特异性 MKP 包括 PP2A 和 PP2C，许多作用于 MAPK 的 DUSPs 已知。活化的 MAP 激酶触发 MAPK 基因的转录。因此，MKPs 通过脱磷酸化在细胞质和细胞核中抑制 MAPK，为 MAPK 信号传导提供负反馈调节机制。一些 MKP 对 ERK 更特异，其他对 JNK 或 p38MAPK 更特异。
英文描述
ERKs are inactivated MAP Kinases are inactivated by a family of protein named MAP Kinase Phosphatases (MKPs). They act through dephosphorylation of threonine and/or tyrosine residues within the signature sequence -pTXpY- located in the activation loop of MAP kinases (pT=phosphothreonine and pY=phosphotyrosine). MKPs are divided into three major categories depending on their preference for dephosphorylating; tyrosine, serine/threonine and both the tyrosine and threonine (dual specificity phoshatases or DUSPs). The tyrosine-specific MKPs include PTP-SL, STEP and HePTP, serine/threonine-specific MKPs are PP2A and PP2C, and many DUSPs acting on MAPKs are known. Activated MAP kinases trigger activation of transcription of MKP genes. Therefore, MKPs provide a negative feedback regulatory mechanism on MAPK signaling, by inactivating MAPKs via dephosphorylation, in the cytoplasm and the nucleus. Some MKPs are more specific for ERKs, others for JNK or p38MAPK.
所含基因
13 个基因