FCGR 激活
中文名称
通路描述
FCGR 与 IgG 包被的免疫复合物的交联导致受体免疫酪氨酸激活基序（ITAMs）的酪氨酸磷酸化，由 SRC 家族膜结合酪氨酸激酶介导。磷酸化的 ITAM 酪氨酸作为 SH2 结构域包含的 SYK 激酶的锚定位点。SYK 的招募和激活对于吞噬作用中 FCGR 介导的信号传导至关重要，但 SYK 在此过程中的确切作用尚不清楚。活化的 SYK 然后传递下游信号，导致肌动蛋白聚合和颗粒内化。
英文描述
FCGR activation Cross-linking of FCGRs with IgG coated immune complexes results in tyrosine phosphorylation of the immuno tyrosine activation motif (ITAMs) of the rececptor by membrane-bound tyrosine kinases of the SRC family. The phosphorylated ITAM tyrosines serve as docking sites for Src homology 2 (SH2) domain-containing SYK kinase. Recruitment and activation of SYK is critical for FCGR-mediated signaling in phagocytosis, but the exact role of SYK in this process is unclear. Activated SYK then transmits downstream signals leading to actin polymerization and particle internalization.
所含基因
25 个基因