吞噬杯形成中肌动蛋白动态的调节
中文名称
通路描述
肌动蛋白细胞骨架对于吞噬作用至关重要，Rho 家族 GTP 酶 RAC 和 CDC42 的成员参与肌动蛋白细胞骨架调节，导致伪足延伸。活跃的 RAC 和 CDC42 通过 WASP 家族蛋白（WASP/N-WASP/WAVE）和 ARP2/3 复合物的成员发挥其作用。在伪足延伸期间，肌动蛋白丝从吞噬杯底部向顶部移动。
英文描述
Regulation of actin dynamics for phagocytic cup formation The actin cytoskeleton is fundamental for phagocytosis and members of the Rho family GTPases RAC and CDC42 are involved in actin cytoskeletal regulation leading to pseudopod extension. Active RAC and CDC42 exert their action through the members of WASP family proteins (WASP/N-WASP/WAVE) and ARP2/3 complex. Actin filaments move from the bottom toward the top of the phagocytic cup during pseudopod extension.
所含基因
74 个基因
ABI1
ABI2
ABL1
ACTB
ACTG1
ACTR2
ACTR3
ARPC1A
ARPC1B
ARPC2
ARPC3
ARPC4
ARPC5
BAIAP2
BRK1
BTK
CD247
CD3G
CDC42
CFL1
CRK
CYFIP1
CYFIP2
DOCK1
ELMO1
ELMO2
FCGR1A
FCGR2A
FCGR3A
HSP90AA1
HSP90AB1
IGHG1
IGHG2
IGHG3
IGHG4
IGHV
IGKC
IGKVA18
IGLC1
IGLC2
IGLC3
IGLC6
IGLC7
IGLV
LIMK1
MAPK1
MAPK3
MYH2
MYH9
MYO10
MYO1C
MYO5A
MYO9B
NCK1
NCKAP1
NCKAP1L
NCKIPSD
NF2
PAK1
PTK2
RAC1
SYK
VAV1
VAV2
VAV3
WAS
WASF1
WASF2
WASF3
WASL
WASP
WIPF1
WIPF2
WIPF3