溶质磷脂在吞噬作用中的作用
中文名称
通路描述
磷脂酶在吞噬作用中起着关键作用，通过产生必要的第二信使。吞噬信号传导的早期步骤是PIP2和IP3与吞噬杯的结合。这些是由磷脂酰肌醇激酶和磷脂酶产生的。PI3K已被证明在吞噬杯中积累，并将PI (4,5)P2转化为PI (3,4,5)P3。这些磷脂酰肌醇能够结合并增加调节肌动蛋白细胞骨架的蛋白活性。磷脂酶是脂质修饰酶，产生脂质介质，如二酰甘油 (DAG)、花生四烯酸 (AA) 和 IP3。磷脂酶 PLA、PLC 和 PLD 已被证明参与抗体 (IgG) 介导的吞噬作用。PLC 产生的 IP3 刺激从内质网释放钙离子。这种 Ca+2 浓度增加在吞噬杯周围的细胞质中最大。钙离子参与吞噬体形成的各种阶段，包括吞噬性摄入和吞噬体成熟。
英文描述
Role of phospholipids in phagocytosis Phospholipases play an integral role in phagocytosis by generating essential second messengers. An early step in phagocytic signaling is the association of PIP2 and IP3 with the phagocytic cup. These are formed by the activity of phosphoinositol kinases and phospholipases. PI3K is has been shown to accumulate at phagocytic cups and converts PI (4,5)P2 to PI (3,4,5)P3. These phosphoinositides are capable of binding and increasing the activity of proteins that regulate the actin cytoskeleton. Phospholipases are lipid modifying enzymes that produce lipid mediators such as diacylglycerol (DAG), arachidonic acid (AA) and IP3. Phopsholipases PLA, PLC and PLD have been shown to be involved in antibody (IgG) mediated phagocytosis. The PLC product IP3 stimulates release of calcium from the endoplasmic reticulum. This Ca+2 concentration increase is greatest in the cytoplasm surrounding the phagocytic cup. Calcium is involved in the various stages of phagosome formation, including phagocytic ingestion and phagosome maturation.
所含基因
38 个基因